Can High Cholesterol Cause Fatigue? Here’s What to Know

Mar 23, 2025 | 2 min read

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Most people don’t connect fatigue with high cholesterol, and for good reason - cholesterol usually doesn’t cause noticeable symptoms. But when tiredness becomes a daily issue with no clear cause, it’s natural to start looking deeper. 

Could cholesterol be part of the picture? 

It’s not the usual suspect, but in some cases, it could be part of the problem.

 

can high cholesterol cause fatigue

Can High Cholesterol Cause Fatigue?

High cholesterol is usually asymptomatic - that’s why it’s called a “silent condition.” You might feel perfectly fine and still have high cholesterol without knowing it. Many people only discover it after doing a blood test.

To confirm high cholesterol, your doctor will typically recommend a lipid panel, which measures different types of cholesterol in your blood. 

You can’t rely on how you feel to know if your cholesterol is high.

That said, in severe or long-term cases, high cholesterol can have indirect effects on your body and energy levels. It can lead to narrowed or blocked arteries

When that happens, it becomes harder for oxygen-rich blood to reach your muscles and organs. And that can take a toll on your energy. You may experience:

  • Fatigue
  • Weakness
  • Shortness of breath, especially during physical activity

Your heart may also have to work harder to pump blood, which can leave you feeling tired more quickly than usual.

In that case, you can also experience

  • Chest discomfort or tightness
  • Numbness or coldness in hands and feet
  • Blurred vision or trouble focusing
  • Memory fog or difficulty concentrating

These symptoms don’t confirm high cholesterol on their own, but they may signal that it’s time to get checked 

While fatigue isn’t the most common sign of high cholesterol, it can be a result of complications caused by it,  especially when other risk factors are involved.

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Is Your Fatigue Caused by Something Else?

If you’re trying to figure out why you feel so tired, it’s worth looking at other possible causes too. 

While cholesterol might play a role, it’s far from the only possibility.

Here are some of the most common reasons:

  • Not getting enough sleep or dealing with insomnia
  • Stress and anxiety draining your mental energy
  • Anemia (low red blood cells), which means your body isn’t getting enough oxygen
  • Thyroid issues (especially if your thyroid is underactive)
  • Unstable blood sugar levels
  • Dehydration, even mild
  • Vitamin deficiencies, especially B12 or D
  • Lack of physical activity
  • Skipping meals or poor nutrition

If any of these sound familiar, don’t panic - but do pay attention.

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Conclusion

High cholesterol doesn’t typically cause symptoms, but in some cases, it can contribute to fatigue - especially when circulation is affected. 

If you’re feeling tired without a clear reason, it’s worth checking your cholesterol levels and considering other possible causes. 

A simple blood test and a conversation with your doctor can point you in the right direction.

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Please Note!This tool is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always consult a professional before taking any actions.

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